Review article
https://doi.org/10.15255/KUI.2015.050
3-Hydroxypyridin-4-ones (Part I): Preparation and Chelation Ability
Željka Car
orcid.org/0000-0002-7301-6615
; Division of Organic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102A, HR-10 000 Zagreb, Croatia
Vesna Petrović Peroković
; Division of Organic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102A, HR-10 000 Zagreb, Croatia
Srđanka Tomić Pisarović
; Division of Organic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102A, HR-10 000 Zagreb, Croatia
Abstract
Since the discovery of deferiprone in 1982, so far the only 3-hydroxypyridin-4-one chelator for hard metal ions that is clinically approved, these heterocyclic derivatives have become an intensively studied group of compounds. This review presents the two most common synthetic methods used for the preparation of the heterocyclic 3-hydroxypyridin-4-one structure, the Harris method and the direct procedure, as well as the most important physical and chemical parameters needed for the preliminary evaluation of their chelating abilities.
Keywords
3-hydroxypyridin-4-ones; direct synthesis; Harris method; iron(III); chelating agent; physical and chemical properties
Hrčak ID:
169066
URI
Publication date:
8.12.2016.
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