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Original scientific paper

Reactions with N-(1-benzotriazolylcarbonyl)-amino acids. IV. The use of N-(1-benzotriazolylcarbonyl)-amino acid derivates in peptide synthesis

B. Zorc ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia
G. Karlović ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia
I. Butula ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia, Yugoslavia


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Abstract

The use of the 1-benzotriazolylearbonyl-(Bte)-group as an N-protecting and N-activating group in the synthesis of peptides was investigated. Removal of the Btc group from N-Btc-amino acids, their esters and amides under acidic conditions is possible, but has no advantages over removal of benzyloxyearbonyl-(Z)-group.
N-Btc-amino acid esters react with Z-amino acids or Z-dipeptides yielding Z-dipeptide and Z-tripeptide esters, respcetively. This process is aceompanied with separation of benzotriazole and C02. Advantages and disadvantages of this method of peptide bond formation are discussed.

Keywords

Hrčak ID:

176511

URI

https://hrcak.srce.hr/176511

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