Original scientific paper

TUMOR ANTIGENS IN PROSTATE CANCER STRESSFUL COMMUNICATIVE PROBLEMS OF MODERN MAN

Tvrtko Hudolin ; Department of Urology, Zagreb University Hospital Center, Zagreb, Croatia
Ahmad El-Saleh ; Department of Urology, Zagreb University Hospital Center, Zagreb, Croatia
Ljiljana Hlupić ; Department of Pathology, Zagreb University Hospital Center, Zagreb, Croatia
Željko Kaštelan ; Department of Urology, Zagreb University Hospital Center, Zagreb, Croatia

Abstract

This study investigated the immunohistochemical expression of the cancer testis antigen SSX in prostate cancer. SSX expression, with varying staining intensities, was observed in 83% of cancer samples. Substantial heterogeneity of expression was observed within individual samples. SSX expression was significantly higher in Gleason score 7 than in Gleason score 6 cancer (p=0.008). Tumours demonstrating capsular invasion had higher SSX expression than did tumours without capsular invasion (p=0.005). SSX expression did not correlate significantly with prostate-specific antigen level or tumour size. Further studies are needed to investigate SSX expression in prostate cancer and its potential implications for diagnosis and immunotherapy.

Keywords

prostate cancer; tumour antigen; SSX; immunotherapy

Hrčak ID:

183668

URI

https://hrcak.srce.hr/183668

Publication date:

28.6.2017.

Article data in other languages: croatian

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