Review article

https://doi.org/10.15255/KUI.2016.029

Quinone Methides (Part I): Reactive Intermediates in the Chemistry of Phenols and Their Application in Organic Synthesis

Đani Škalamera ; Ruđer Bošković Institute, Bijenička cesta 54, 10 000 Zagreb
Tatjana Šumanovac Ramljak ; Ruđer Bošković Institute, Bijenička cesta 54, 10 000 Zagreb
Antonija Husak ; Ruđer Bošković Institute, Bijenička cesta 54, 10 000 Zagreb

Abstract

Quinone methides (QMs, IUPAC name: quinomethanes) are reactive intermediates which are very important in organic chemistry. Their applications in organic synthesis are widely recognized, which has led to the development of a large number of methods for their generation. They are useful in stereoselective reactions, which open them the way for applications in total synthesis, often for structures that have already shown significant biological activity. This review gives an insight into the methods of synthetic (thermal) generation of QMs and their applications in organic synthesis, with an emphasis on the biological activity of QMs or the products obtained from them in the synthesis.


This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords

quinone methides; phenol derivatives; thermal generation of quinone methides; quinone methides in organic synthesis; antiproliferative activity

Hrčak ID:

185073

URI

https://hrcak.srce.hr/185073

Publication date:

31.7.2017.

Article data in other languages: croatian

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