Review article

https://doi.org/10.5599/admet.5.4.441

Utilizing in vitro transporter data in IVIVE-PBPK: an overview

Pankajini Mallick ; College of Pharmacy, Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Houston, TX 77030, USA

Abstract

In vitro-in vivo extrapolation (IVIVE) integrated in physiologically-based pharmacokinetic (PBPK) models have been increasingly used during drug discovery and development processes to predict human pharmacokinetic (PK) parameters. Drug transporters can influence drug pharmacokinetics and are key aspects contributing to the development of a successful drug. This review provides a snapshot of challenges or shortcomings of in vitro and in vivo techniques for understanding the contribution of drug transporters to a drug’s pharmacokinetics. The paper also describes the potential of IVIVE-PBPK models as prospective approaches to predict the role of drug transporters in drug discovery and development.

Keywords

Pgp; Bile acid transporter; Drug transporters; Drug metabolizing enzymes; Drug induced liver injury

Hrčak ID:

191420

URI

https://hrcak.srce.hr/191420

Publication date:

24.12.2017.

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