ADMET and DMPK, Vol. 6 No. 1, 2018.
Short communication, Note
https://doi.org/10.5599/admet.6.1.497
Dissolution rates of ciprofloxacin and its cocrystal with resorcinol
Clara Ràfols
; Departament de Química Analítica and Institut de Biomedicina (IBUB), Universitat de Barcelona; Martí i Franquès 1-11, 08028 Barcelona, Spain
Hanan Fael
; Departament de Química Analítica and Institut de Biomedicina (IBUB), Universitat de Barcelona; Martí i Franquès 1-11, 08028 Barcelona, Spain
Elisabet Fuguet
; Departament de Química Analítica and Institut de Biomedicina (IBUB), Universitat de Barcelona; Martí i Franquès 1-11, 08028 Barcelona, Spain
Breeze Outhwaite
; Sirius Analytical, Forest Row, East Sussex, UK
Samuel Lee
; Sirius Analytical, Forest Row, East Sussex, UK
Rebeca Ruiz
; Sirius Analytical, Forest Row, East Sussex, UK
Abstract
The synthesis of cocrystals is presented as an alternative to improve the properties of active pharmaceutical ingredients, especially those related to solubility and dissolution rate. In this work the dissolution rate of ciprofloxacin, a zwitterionic fluoroquinolone antibiotic, has been compared to its cocrystal with resorcinol. To this end, dissolution rate has been determined at several biorelevant pH values, and also in two simulated gastrointestinal fluids (FeSSIF and FaSSIF). Results show that both, ciprofloxacin and the cocrystal, dissolve more slowly as pH increases (from 2.0 to 7.4), as ionization degree of ciprofloxacin decreases. In addition, dissolution is not enhanced by the components of the gastrointestinal fluids.
Keywords
Dissolution rate; cocrystal; ciprofloxacin; solid state; FaSSIF; FeSSIF; Simulated gastrointestinal fluid
Hrčak ID:
196402
URI
Publication date:
25.3.2018.
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