Review article
https://doi.org/10.17113/ftb.56.01.18.5444
Genetically Engineered Strains: Application and Advances for 1,3-Propanediol Production from Glycerol
Miaomiao Yang
; School of Food and Biological Engineering, Jiangsu University
Junhua Yun
; School of Food and Biological Engineering, Jiangsu University
Huanhuan Zhang
; School of Food and Biological Engineering, Jiangsu University
Tinashe A. Magocha
; School of Food and Biological Engineering, Jiangsu University
Hossain Zabed
; School of Food and Biological Engineering, Jiangsu University
Yanbo Xue
; School of Food and Biological Engineering, Jiangsu University
Ernest Fokum
; School of Food and Biological Engineering, Jiangsu University
Wenjing Sun
; School of Food and Biological Engineering, Jiangsu University
Xianghui Qi
; School of Food and Biological Engineering, Jiangsu University
Abstract
1,3-Propanediol (1,3-PD) is one of the most important chemicals widely used as monomers for synthesis of some commercially valuable products, including cosmetics, foods, lubricants and medicines. Although 1,3-PD can be synthesized both chemically and biosynthetically, the latter offers more merits over chemical approach as it is economically viable, environmentally friendly and easy to carry out. The biosynthesis of 1,3-PD can be done by transforming glycerol or other similar substrates using some bacteria, such as Clostridium butyricum and Klebsiella pneumoniae. However, these natural microorganisms pose some bottlenecks like low productivity and metabolite inhibition. To overcome these problems, recent research efforts have been focused more on the development of new strains by modifying the genome through different techniques, such as mutagenesis and genetic engineering. Genetically engineered strains obtained by various strategies cannot only gain higher yield than wild types, but also overcome some of the barriers in production by the latter. This review paper presents an overview on the recent advances in the technological approaches to develop genetically engineered microorganisms for efficient biosynthesis of 1,3-PD.
Keywords
glycerol; 1,3-propanediol; biosynthesis; genetically engineered strain; mutagenesis
Hrčak ID:
197356
URI
Publication date:
30.3.2018.
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