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Acta medica Croatica : Časopis Akademije medicinskih znanosti Hrvatske, Vol. 72 No. 1, 2018.

Professional paper

VENTILATOR ASSOCIATED PNEUMONIA TREATED WITH COLISTIN – RETROSPECTIVE 4-YEAR ANALYSIS

TAJANA ZAH BOGOVIĆ ; University of Zagreb, School of Medicine, Zagreb University Hospital Center, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb, Croatia
MARKO BOGOVIĆ ; University of Zagreb, School of Medicine, Zagreb University Hospital Center, Department of Surgery, Zagreb, Croatia
DINKO TONKOVIĆ ; University of Zagreb, School of Medicine, Zagreb University Hospital Center, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb, Croatia
DANIELA BANDIĆ PAVLOVIĆ ; University of Zagreb, School of Medicine, Zagreb University Hospital Center, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb, Croatia
MLADEN PERIĆ ; University of Zagreb, School of Medicine, Zagreb University Hospital Center, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb, Croatia
SLOBODAN MIHALJEVIĆ ; University of Zagreb, School of Medicine, Zagreb University Hospital Center, Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb, Croatia
BORIS TOMAŠEVIĆ ; Department of Anesthesiology, Resuscitation and Intensive Care, Zagreb, Croatia

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Abstract

The aim of the study was to determine the incidence and characteristics of ventilator associated pneumonia (VAP) in patients with multi-drug resistant gram-negative (MDR-GN) pathogens. Retrospective data from the hospital information system and medical charts were analyzed. The study included 58 patients (age 70.41±13.0 years) treated in the Intensive Care Unit (ICU) of the Department of Anesthesiology, Resuscitation and Intensive Care from January 2013 till December 2016, diagnosed with VAP caused by GN pathogens and treated with colistin. The most common cause of MDR-GN VAP was Pseudomonas aeruginosa in 46 (79.3%) patients, followed by Acinetobacter baumannii in 28 (48.3%) and Klebsiella pneumoniae in 7 (12.1%) patients. Thirty-four (58.6%) patients had abdominal diagnosis. The median ASA value was 3. Twenty-seven (46.6%) patients had emergency operation. The mean Simplifi ed Acute Physiology Score (SAPS II) was 53.57±13.8, median 53.0 (range 38-73). In conclusion, the predominant cause of MDR-GN VAP infection in our ICU was multi-resistant Pseudomonas aeruginosa that is treated with colistin. The major patient characteristics were age older than 70, ASA III classifi cation implying serious systemic illness, urgent operation in 47% of patients, and median SAPS II classifi cation 53.

Keywords

ventilator-associated pneumonia; mechanical ventilation; colistin

Hrčak ID:

197723

URI

https://hrcak.srce.hr/197723

Publication date:

3.4.2018.

Article data in other languages: croatian

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