Professional paper

https://doi.org/10.15836/ccar2018.270

MicroRNA in Chronic Kidney Disease and Heart Failure

Anja Ivošević ; University of Zagreb School of Medicine, Zagreb, Croatia
Marija Magdalena Jakopović ; University of Zagreb School of Medicine, Zagreb, Croatia
Marija Stanković ; University of Zagreb School of Medicine, Zagreb, Croatia
Ingrid Prkačin orcid.org/0000-0002-5830-7131 ; University of Zagreb School of Medicine, Zagreb, Croatia; University Hospital «Merkur», Zagreb, Croatia

Abstract

MicroRNA (miRNA) are small non-coding single-strand RNA molecules built from 21-25 nucleotides that regulate gene expression at the post-transcription level. More than a thousand different miRNA are coded in the human genome. During the last few years, it has been found that miRNA are involved in different biological processes such as differentiation, proliferation, and apoptosis of cells. miRNA is part of the pathogenesis of many diseases in humans, such as heart failure, diabetes, obesity, kidney, infectious and malign diseases, and genetic disorders. Much evidence speaks in favor of the significance of miRNA in the development of the kidneys and physiology of the heart. It is thus not surprising that a disorder of miRNA regulation can be observed in many different kidney and heart diseases. The discovery that circulating miRNA can be detected in the serum and plasma and that their expression can vary due to disease represents a significant potential for their use as a new biomarker. Therapy based on miRNA can act by either restoring their function or blocking their expression and activity, making it very promising.

Keywords

microRNAs; chronic kidney disease; heart failure

Hrčak ID:

204775

URI

https://hrcak.srce.hr/204775

Publication date:

3.9.2018.

Article data in other languages: croatian

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