Original scientific paper

https://doi.org/10.20471/acc.2018.57.s1.05

DIJAGNOSTIČKI ZNAČAJ BIOPSIJE PROSTATE VOĐENE KOGNITIVNOM FUZIJOM MULTIPARAMETRIJSKE MAGNETNE REZONANCE I TRANSREKTALNOG ULTRAZVUKA (mpmri-TRUS) KOD BOLESNIKA S PRETHODNO NEGATIVNOM TRUS VOĐENOM BIOPSIJOM

Igor Tomašković orcid.org/0000-0003-4182-9707 ; Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb; Faculty of Medicine, Josip Juraj Strossmayer University, Osijek, Croatia; Referral Center for Prostate Tumors of the Ministry of Health, Republic of Croatia
Ivan Pezelj ; Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb; Referral Center for Prostate Tumors of the Ministry of Health, Republic of Croatia
Karolina Bolanča Čulo ; Department of Radiology, Sestre milosrdnice University Hospital Center
Luka Novosel ; Department of Radiology, Sestre milosrdnice University Hospital Center
Sven Nikles ; Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb; Referral Center for Prostate Tumors of the Ministry of Health, Republic of Croatia
Miroslav Tomić ; Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb; Referral Center for Prostate Tumors of the Ministry of Health, Republic of Croatia
Ante Reljić ; Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb; Referral Center for Prostate Tumors of the Ministry of Health, Republic of Croatia
Josip Katušić ; Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb; Referral Center for Prostate Tumors of the Ministry of Health, Republic of Croatia
Matej Knežević ; Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb; Referral Center for Prostate Tumors of the Ministry of Health, Republic of Croatia
Matea Pirša ; Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb; Referral Center for Prostate Tumors of the Ministry of Health, Republic of Croatia
Božo Kruslin ; Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center
Monika Ulamec ; Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center
Boris Ružić ; Department of Urology, Sestre milosrdnice University Hospital Center, Zagreb; Referral Center for Prostate Tumors of the Ministry of Health, Republic of Croatia

Abstract

U ovoj prospektivnoj kliničkoj studiji cilj je odrediti stopu detekcije raka prostate biopsije vođene kognitivnom fuzijom multiparametrijske magnetne rezonance i transrektalnog ultrazvuka (mpMRI-TRUS) kod bolesnika s prethodno negativnom TRUS vođenom biopsijom. U razdoblju od 1. 10. 2016. do 1. 7. 2017. kod 101 uzastopnog bolesnika s povišenim prostata specifičnim antigenom (PSA) i/ili pozitivnim digitorektalnim pregledom, a nakon negativne prve TRUS biopsije je učinjena druga, ponovljena biopsija prostate. Kod 24 bolesnika učinjena je, u skladu sa Smjernicama Europskog urološkog društva, prethodna mpMRI i potom kognitivna fuzijska biopsija prostate s 8-10 sistemskih cilindara i 1-3 ciljane biopsije prema mpMRI nalazu. Kod 77 bolesnika je učinjena samo klasična, ponovljena TRUS biopsija bez prethodne slikovne obrade. Kod bolesnika s mpMRI, stopa detekcije raka prema PIRADSU-v2 je PIRADS 1, n = 0; PIRADS 2, n = 0; PIRADS 3, n = 0; PIRADS 4, n = 6/8 (75%) i PIRADS 5, n = 2/3 (67%). U skupini bolesnika s MR-TRUS kognitivnom fuzijskom biopsijom stopa detekcije raka prostate je 8/24 (33%), dok je u kontrolnoj skupini stopa detekcije 12/77 (16%), što se pokazalo statistički značajnom razlikom (t test; p=0.037, CI 95% je 0.01 to 0.37). Bolesnici s PIRADS ≤ 3 (54%) su mogli izbjeći biopsiju.

Keywords

Rak prostate; Magnetna rezonancija; Biopsija prostate

Hrčak ID:

207888

URI

https://hrcak.srce.hr/207888

Publication date:

1.10.2018.

Article data in other languages: english

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