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RATIONAL USE OF ANTIMICROBIAL DRUGS IN CLINICAL PRACTICE BY IMPLEMENTING ANTIMICROBIAL STEWARDSHIP PROGRAMS

SANJA SAKAN orcid.org/0000-0002-9551-413X ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia
DAVORKA PRAJDIĆ-PREDRIJEVAC ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia
VLADO JURANKO ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia
MLADEN NOVKOSKI ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia
ZDENKO POVŠIĆ-ČEVRA ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia
JANKO SZAVITS-NOSSAN ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia
IGOR ŠESTO ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia
MARIJA RAZUM ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia
LUKA ROTKVIĆ ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia
IVAN BUDIMIR orcid.org/0000-0002-0202-9208 ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia
NIVES TODORIĆ ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia
NATAŠA ANDRIJAŠEVIĆ ; Sveti Duh University Hospital, Department of Clinical Microbiology and Hospital Infections, Zagreb, Croatia
ZVONIMIR ANTE KORDA ; Magdalena Special Hospital for Cardiovascular Surgery and Cardiology, Krapinske Toplice, Croatia

Abstract

According to studies, about 50% of antimicrobial drugs are prescribed unnecessarily and inappropriately in hospitals and other healthcare institutions. Besides the high prevalence of Clostridium diffi cile infection, of particular concern is the increase in bacterial pathogen resistance to fl uoroquinolones and vancomycin-resistant enterococci. Additionally, infections due to bacterial pathogens completely resistant to carbapenems are currently emerging in Europe. In this case, therapeutic options are limited to the use of the polymyxin antibiotic colistin, which is old and has many adverse and toxic events. Growing evidence demonstrates that hospital programs dedicated to improving the use of antimicrobial therapy, referred to as Antimicrobial Stewardship Programs (ASP), can optimize treatment of infections, reduce adverse events of antimicrobial therapy, improve patient safety and quality of care, and at the same time signifi cantly reduce hospital costs, mortality rate and length of hospital stay. Therefore, the US Centers for Disease Control and Prevention and European Centre for Disease Prevention and Control recommend that every acute care hospital implement the multidisciplinary ASP in daily clinical practice.

Keywords

antibiotic; hospital; infection; resistance

Hrčak ID:

208537

URI

https://hrcak.srce.hr/208537

Publication date:

16.11.2018.

Article data in other languages: croatian

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