ADMET and DMPK, Vol. 7 No. 1, 2019.
Editorial
https://doi.org/10.5599/admet.667
Physiologically based pharmacokinetic (PBPK) modeling and simulation in drug discovery and development
Abdul Naveed Shaik
; Simulations Plus Inc., Lancaster, CA. USA
Ansar Ali Khan
; GVK Biosciences. Hyderabad, TS. India
Abstract
Physiologically based pharmacokinetic (PBPK) modeling is a mechanistic or physiology based mathematical modeling technique which integrates the knowledge from both drug-based properties including physiochemical and biopharmaceutical properties and system based or physiological properties to generate a model for predicting the absorption, distribution, metabolism and excretion (ADME) of a drug as well as pharmacokinetic behavior of a drug in preclinical species and humans.
Keywords
Physiologically based pharmacokinetic modeling; PBPK
Hrčak ID:
217375
URI
Publication date:
23.2.2019.
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