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Croatica Chemica Acta, Vol. 92 No. 1, 2019.

Original scientific paper

https://doi.org/10.5562/cca3475

Helichrysum italicum (Roth) G. Don subsp. italicum from Herzegovina: Volatile Composition, Variations during Seasons, Total Polyphenols, Acetylcho-linesterase Inhibition and Antioxidant Activity

Stanislava Talić orcid id orcid.org/0000-0001-7633-4312 ; Department of Chemistry, Faculty of Science and Education, University of Mostar, Matice hrvatske bb, 88000 Mostar, Bosnia and Herzegovina
Ilijana Odak orcid id orcid.org/0000-0002-6883-8470 ; Department of Chemistry, Faculty of Science and Education, University of Mostar, Matice hrvatske bb, 88000 Mostar, Bosnia and Herzegovina
Anita Martinović Bevanda ; Department of Chemistry, Faculty of Science and Education, University of Mostar, Matice hrvatske bb, 88000 Mostar, Bosnia and Herzegovina
Nikolina Crnjac ; Department of Chemistry, Faculty of Science and Education, University of Mostar, Matice hrvatske bb, 88000 Mostar, Bosnia and Herzegovina
Mate Paštar ; Department of Chemistry, Faculty of Science and Education, University of Mostar, Matice hrvatske bb, 88000 Mostar, Bosnia and Herzegovina

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Abstract

The chemical composition of essential oils isolated from immortelle (Helicrysum italicum subsp. italicum) collected in Herzegovina during five different periods, was investigated by GC/MS analysis. The main compounds were a-pinene (15.7 %) and γ-curcumene (12.8 %), followed by 4,6,9-trimethyldec-8-en-3,5-dione (8.7 %), neryl acetate (6.9 %), limonene (6.4 %) and β-selinene (5.3 %). In total, 69 components were identified whose share changed over the vegetative cycle. Antioxidant activity of methanolic extracts of immortelle were determined according to DPPH (IC50 = 23–34 μg/mL) and FRAP (29 μg/mL is equivalent to 1.1‒2.2 mM Fe2+) methods. Acetylcholinesterase inhibitory potential, investigated by modified Ellman’s assay and determined as IC50 values, were 340–440 μg/mL for methanol extracts and 135 μg/mL for essential oil. Metanolic extracts showed strong antioxidant activity and potential to inhibit AChE. Essential oil possesses complex chemical composition, inhibition activity of AChE and weak antioxidant capacity.

This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords

Helichrysum italicum subsp. italicum; Asteraceae; essential oil composition; α-pinene; γ-curcumene; antioxidant activity

Hrčak ID:

218125

URI

https://hrcak.srce.hr/218125

Publication date:

28.1.2019.

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