Meeting abstract

INITIAL ERYTHROPOIETIC PARAMETERS PREDICTING RETICULOCYTE INCREASE IN LOWER TO MODERATE ALTITUDE AEROBIC ACTIVITY

Matea Sedlaček ; Faculty of Kinesiology, Horvacanski zavoj 15, Zagreb, Croatita
Lana Ružić ; Faculty of Kinesiology, Horvacanski zavoj 15, Zagreb, Croatita

Abstract

Introducation: Although high altitude and its benefits on human physiology is vastly studied area, it is still often seen that the responses are strongly individual. The altitudes up to 2000m had not been thoroughly investigated, although those are usual altitudes on which recreational population will spend their active holidays and might get some hematological benefits. It would be of great importance in athletes as well as in general population to know beforehand who could get the greatest improvements in red blood cell parameters (RBC) after the return to sea level. The aim of the study was to search for predictive power of initial ferritin levels, erythrocyte counts and erythropoietin concentration in relative reticulocyte increase.
Methods: The experimental group (N=17) underwent an intervention, a typical 10-day ski-trip. They slept at on 1250 m and performed 5-6 hours of aerobic activity (skiing) at 1250-2000m altitude. The initial and final (before and after the trip) ferritin levels, reticulocyte count, red blood cell count and erythropoietin were measured.
Results: The whole multiple regression model could explain 27% of the reticulocyte change (R=0,522; R2=0,273; Adjusted R2=0,105; F(3,13)=1,627; p<0,231; Std. Error of Estimate: 2,106) and showed that a variable in model which had the strongest predictive power was initial erythropoietin concentration. There was a significant negative relationship between initial erythropoietin count and the relative reticulocyte increase (b* = 0.65; Std. Err of b*= 0.300; p<0.05). The initial ferritin reserves were not a good predictor of reticulocyte response. The initial erythrocyte count could explain the reticulocyte increase a bit better but that predictive power was not statistically significant.
Concsluion: In conclusion, the ones with lower initial erythropoietin concentration had stronger reticulocyte response, and it could be seen even on lower to moderate altitude. This might implicit possible RBC benefits for general population, who spend their winter holidays actively.

Keywords

erythropoietin; reticulocyte; high altitude; aerobic activity; ferritin

Hrčak ID:

218612

URI

https://hrcak.srce.hr/218612

Publication date:

31.12.2018.

Article data in other languages: croatian

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