Original scientific paper
https://doi.org/10.5599/jese.652
Electrochemical reduction of artemisinin: Chromatographic identification of bulk electrolysis products
Faraja Obwayo
; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA
Zahilis Mazzochette
; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA
Amos Mugweru
; Department of Chemistry and Biochemistry, Rowan University, Glassboro, NJ 08028, USA
Abstract
Artemisinin is a naturally occurring sesquiterpene lactone with an endo-peroxide bond. This drug is used for treatment of many diseases including malaria. The reduction of this molecule on an electrode surface was carried out by cyclic voltammetry as well as amperometry. Cyclic voltammetry of artemisinin generated one prominent peak wave at -1.0 V and another, smaller one at -0.3 V vs Ag/AgCl reference electrode. The bulk electrolysis of artemisinin on a carbon electrode generated two other irreversible peak waves at around -0.7 and -0.1 V. The concentration of the products was dependent on the time of electrolysis. LC-MS was used to determine the bulk electrolysis products of artemisinin. Initially dihydroartemisinin was generated as the main reduction product. Other reduction products were formed after further reduction of dyhidroartemisinin.
Keywords
Cyclic voltammetry; dyhidroartemisinin; electrochemical reduction; bulk electrolysis; LC-MS
Hrčak ID:
219924
URI
Publication date:
6.5.2019.
Visits: 905 *