Original scientific paper
https://doi.org/10.15255/KUI.2019.007
Electrospun Polycaprolactone for Controlled Drug Delivery
Emi Govorčin Bajsić
; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia
Emilija Zdraveva
orcid.org/0000-0003-2845-8630
; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia
Budimir Mijović
; University of Zagreb Faculty of Textile Technology, Croatia
Tamara Holjevac Grgurić
; University of Zagreb, Faculty of Metallurgy, Sisak, Croatia
Mirna Tominac Trcin
; University Hospital Sisters of Charity, Tissue bank, Clinic for Traumatology, Croatia
Tea Zubin Ferri
; Materials’ Research Centre of the Istrian County – METRIS, Pula, Croatia
Abstract
Tissue engineering is a good alternative for the development of tissue or potential organs from the patient’s own cell material in order to reduce the problem of organ transplant deficiency. Electrospun materials are good candidates for use in biomedicine, as scaffolds for tissue cells culture. Additionally, these scaffolds can provide controlled drug release in tissue regenerative therapies. In this paper, controlled release of antibiotic Cefuroxim (CFU), which is used for ocular tissue therapy, was investigated. The polycaprolactone scaffolds were prepared by electrospinning with the addition of CFU in the amount of 1, 2, 5, and 10 wt %. The successful antibiotic capsulation was confirmed by the new characteristic peaks appearing in the FTIR spectra of the electrospun blends. With the addition of antibiotic and increase in its concentration, fibres with more uniform morphology and less deformations along the fibres length were obtained. The release of antibiotic from PCL scaffolds was determined by UV–VIS spectrophotometer. Obtained was an increase in absorption of antibiotics with time and with increased drug concentration in the scaffolds.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords
electrospinning; polycaprolactone; Cefuroxime; scaffolds; tissue engineering
Hrčak ID:
225273
URI
Publication date:
7.10.2019.
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