Original scientific paper
https://doi.org/10.15255/KUI.2019.032
3D-Printed Oral Dosage Forms Loaded with Dispersion of Oil and Active Ingredient
Andrea Milićević
; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia
Matija Gretić
orcid.org/0000-0002-6895-229X
; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia
Gordana Matijašić
orcid.org/0000-0002-8521-2154
; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia
Abstract
In this study, the possibility of producing pharmaceutical dosage forms by 3D printing technology is examined. In vitro dissolution tests were performed with printed dosage forms, and the results analysed in Microsoft Excel Add-In, DDSolver. 3D printing has provided six different models of solid dosage forms. The results of dissolution test have shown release profiles with initial time delay. The profiles are described by the Peppas-Sahlin model. It is shown that 3D printing technology has the potential to become a method for quick and simple production of personalized dosage forms with delayed release.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords
3D print; personalized medicines; delayed release; release profiles; Peppas-Sahlin model
Hrčak ID:
225282
URI
Publication date:
7.10.2019.
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