Review article

https://doi.org/10.26800/LV-141-7-8-26

Myelodysplastic syndromes – new discoveries and an “old” morphology

Gordana Kaić ; Zavod za kliničku citologiju i citogenetiku, KB Merkur, Zagreb
Biljana Jelić Puškarić ; Zavod za kliničku citologiju i citogenetiku, KB Merkur, Zagreb
Marina Pažur ; Zavod za kliničku citologiju i citogenetiku, KB Merkur, Zagreb
Mia Šunjić Stakor ; Zavod za kliničku citologiju i citogenetiku, KB Merkur, Zagreb
Slobodanka Ostojić Kolonić ; Zavod za hematologiju, Klinika za unutarnje bolesti, KB Merkur, Zagreb; Medicinski fakultet Sveučilišta u Zagrebu, Zagreb
Delfa Radić Krišto ; Zavod za hematologiju, Klinika za unutarnje bolesti, KB Merkur, Zagreb, Medicinski fakultet Sveučilišta u Osijeku, Osijek
Marko Martinović ; Zavod za hematologiju, Klinika za unutarnje bolesti, KB Merkur, Zagreb
Ika Kardum-Skelin ; Zavod za kliničku citologiju i citogenetiku, KB Merkur, Zagreb, Medicinski fakultet Sveučilišta u Zagrebu, Zagreb

Abstract

Myelodysplastic syndromes (MDS) are a heterogenous group of diseases sharing some clinical and morphological features. Their cause is unknown. Since the rapid development of molecular genetics allows an insight into underlying genetic aberrations, today it is possible to determine some pathogenetic mechanisms in MDS. In this presentation we would like to explain some of the discoveries in this area and their connection to the
myelodysplastic phenotype as seen in everyday cytomorphology work.

Keywords

MYELODYSPLASTIC SYNDROMES – genetics, pathology; ERYTHROPOIESIS – genetics; MUTATION; CHROMOSOME ABERRATIOS; CHROMOSOMES, HUMAN, PAIR 5 – genetics; CHROMOSOME DELETION; RIBOSOMAL PROTEINS – genetics; RIBONUCLEOPROTEINS – genetics; RNA SPLICING FACTORS – genetics; PHENOTYPE

Hrčak ID:

225756

URI

https://hrcak.srce.hr/225756

Publication date:

27.9.2019.

Article data in other languages: croatian

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