Review article
https://doi.org/10.2478/aiht-2020-71-3437
Oxidative stress under general intravenous and inhalation anaesthesia
Sandra Alavuk Kundović
; Children Hospital Zagreb, Department of Anaesthesiology, Reanimatology and Intensive Medicine, Zagreb, Croatia
Dubravka Rašić
; Institute for Medical Research and Occupational Health, Toxicology Unit, Zagreb, Croatia
Ljiljana Popović
; Children Hospital Zagreb, Department of Anaesthesiology, Reanimatology and Intensive Medicine, Zagreb, Croatia
Maja Peraica
; Institute for Medical Research and Occupational Health, Toxicology Unit, Zagreb, Croatia
Ksenija Črnjar
; Children Hospital Zagreb, Department of Anaesthesiology, Reanimatology and Intensive Medicine, Zagreb, Croatia
Abstract
Oxidative stress occurs when reactive oxygen species (ROS) production overwhelms cell protection by antioxidants. This review is focused on general anaesthesia-induced oxidative stress because it increases the rate of complications and delays recovery after surgery. It is important to know what effects of anaesthetics to expect in terms of oxidative stress, particularly in surgical procedures with high ROS production, because their either additive or antagonistic effect may be pivotal for the outcome of surgery. In vitro and animal studies on this topic are numerous but show large variability. There are not many human studies and what we know has been learned from different surgical procedures measuring different endpoints in blood samples taken mostly before and after surgery. In these studies most intravenous anaesthetics have antioxidative properties, while volatile anaesthetics temporarily increase oxidative stress in longer surgical procedures.
Keywords
glutathione; malondialdehyde; reactive oxygen species; superoxide dismutase; TBARS
Hrčak ID:
243866
URI
Publication date:
22.9.2020.
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