Professional paper

TREATMENT OF MULTIPLE SCLEROSIS WITH CLADRIBINE – A RETROSPECTIVE ONE-YEAR ANALYSIS AT DEPARTMENT OF NEUROLOGY, SESTRE MILOSRDNICE UNIVERSITY HOSPITAL CENTRE IN ZAGREB

NEVENA GRBIĆ orcid.org/0000-0003-1537-3734 ; Sestre milosrdnice University Hospital Centre, Department of Neurology, Referral Centre for Neuroimmunology and Neurogenetics of the Ministry of Health, Zagreb, Croatia
MILJENKA-JELENA JURAŠIĆ ; Sestre milosrdnice University Hospital Centre, Department of Neurology, Referral Centre for Neuroimmunology and Neurogenetics of the Ministry of Health, Zagreb, Croatia
LUCIJA ZADRO MATOVINA ; Sestre milosrdnice University Hospital Centre, Department of Neurology, Referral Centre for Neuroimmunology and Neurogenetics of the Ministry of Health, Zagreb, Croatia
IRIS ZAVOREO orcid.org/0000-0001-9358-1665 ; Sestre milosrdnice University Hospital Centre, Department of Neurology, Referral Centre for Neuroimmunology and Neurogenetics of the Ministry of Health, Zagreb,University of Zagreb, Faculty of Kinesiology, Zagreb, Croatia
IVANA HUSTIĆ orcid.org/0000-0002-4481-1281 ; Sestre milosrdnice University Hospital Centre, Department of Neurology, Referral Centre for Neuroimmunology and Neurogenetics of the Ministry of Health, Zagreb, Croatia
VANJA BAŠIĆ KES ; Sestre milosrdnice University Hospital Centre, Department of Neurology, Referral Centre for Neuroimmunology and Neurogenetics of the Ministry of Health, Zagreb, University of Zagreb, School of Dental Medicine, Zagreb, Josip Juraj Strossmayer University of Osijek, School of Medicine, Osijek, Croatia

Abstract

Cladribine (Mavenclad®, Merck Europe, The Netherlands) is a drug used in patients with highly active multiple sclerosis (MS). The exact mechanism is not known but it is considered that drug affects the function of DNA and mitochondria leading to apoptosis of lymphocytes. The effi cacy and safety of cladribine were evaluated in a randomized, double-blind, placebocontrolled clinical trial (CLARITY study) and later on in studies resulting from this study. Patients with relapsing-remitting MS (RRMS) who received cladribine had a statistically signifi cant improvement in the annual rate of relapse, proportion of relapse-free patients and proportion of patients without persistent disability. The aim of this study was to analyze MS patients treated with cladribine at the Department of Neurology, Sestre milosrdnice University Hospital Centre and to compare the results with the existing fi ndings on the drug. This retrospective one-year analysis included patients eligible for cladribine treatment. In total, cladribine was administered to 15 patients. Of these, 46% of patients had previously received fi rst-line immunomodulatory therapy and 53% of patients had not previously undergone immunomodulatory therapy. After one year, before applying second drug cycle, there were no relapses in 66% of patients. In total, there were 20% of side effects, mostly skin reactions. Analysis of data on our group of patients revealed that some of the results were consistent with the CLARITY study, and certain data were approximate to this study. Also, drug administration was associated with a small proportion of side effects. However, additional analysis in a greater patient sample is required, and we plan to extend this study and provide new information in the future.

Keywords

multiple sclerosis; cladribine; treatment; experience

Hrčak ID:

244547

URI

https://hrcak.srce.hr/244547

Publication date:

6.10.2020.

Article data in other languages: croatian

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