Review article
https://doi.org/10.21860/medflum2020_245229
Effects of cold ischemia during kidney transplantation: pathophysiology of damage and cold storage preservation solutions
Alojzije Lacković
; Zavod za anatomiju, Medicinski Fakultet, Sveučilište u Rijeci, Rijeka, Hrvatska
Tanja Ćelić
; Zavod za anatomiju, Medicinski Fakultet, Sveučilište u Rijeci, Rijeka, Hrvatska
Josip Španjol
; Klinika za urologiju, Klinički bolnički centar Rijeka, Rijeka, Hrvatska
Abstract
Ischemic-reperfusion injury is important cause of transplanted kidney decreased function. So far many risk factors have been identified, which may increase the probability of its occurrence, the most important one is duration of the cold ischemia. The main cause of tissue damage in cold ischemia is lack of oxygen, which leads to a decreased concentration of adenosine triphosphate (ATP) and decrease in Na/K-ATPase activity. More complex and severe form of tissue damage is caused by re-establishment of circulation, known as reperfusion, which leads to increased oxygen level in the cells and creation of reactive oxygen species (ROS). ROS cause damage of the DNA, proteins, and lipids of cell membrane. Human body is partially protected from effects of ROS by its own antioxidant enzymatic systems, such as superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase. In order to prevent occurrence of these impairments, different organ preservation solutions can be used during cold ischemia period.
Keywords
cold ischemia; kidney transplantation; preservation solutions, organ; reactive oxygen species
Hrčak ID:
245229
URI
Publication date:
1.12.2020.
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