Short communication, Note

https://doi.org/10.2478/v10007-008-0010-7

N-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

JULIJA MATIJEVIĆ-SOSA ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
ITA SAMARŽIJA ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
LORENA HONOVIĆ ; Clinical Laboratory, General Hospital Pula, Pula, Croatia
BLAŽENKA JURIŠIĆ ; Agency for Medicinal Products and Medicinal Devices of Republic of Croatia, Zagreb

Abstract

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg1 body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg1 body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible

Keywords

N-phthaloyl-glycine-hydroxamic acid; iron chelators; iron overload

Hrčak ID:

22674

URI

https://hrcak.srce.hr/22674

Publication date:

1.6.2008.

Article data in other languages: croatian

Visits: 2.072 *