Original scientific paper

https://doi.org/10.15255/KUI.2020.023

Release Rate Enhancement of Lurasidone Hydrochloride from Orally Disintegrating Tablets using Lyophilisation

Josipa Skočibušić orcid.org/0000-0001-5050-5144 ; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia
Joško Barbarić orcid.org/0000-0001-9539-8717 ; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia
Krunoslav Žižek ; Faculty of Chemical Engineering and Technology University of Zagreb, Marulićev trg 19 10 000 Zagreb, Croatia

Abstract

This paper investigates the possibilities for release rate enhancement of lurasidone hydrochloride, a second-generation antipsychotic, by preparing solid dispersions via lyophilisation process. FTIR, DSC, and XRPD measurements have been performed in order to detect potential interactions between lurasidone hydrochloride and polymer matrices that might significantly increase drug solubility and provide faster release from the dosage form. Such solid dispersions and excipients have been used in the preparation of tablets that disintegrate in less than 3 min. In vitro dissolution profiles indicate a higher drug release rate from disintegrating tablets in comparison to pure LRS HCl.




This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords

lurasidone hydrochloride; solid dispersion; lyophilisation; orally disintegrating tablet; drug release

Hrčak ID:

247621

URI

https://hrcak.srce.hr/247621

Publication date:

14.12.2020.

Article data in other languages: croatian

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