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Technologica Acta : Scientific/professional journal of chemistry and technology, Vol. 13 No. 2, 2020.

Original scientific paper

https://doi.org/10.5281/zenodo.4540207

Synthesis, characterization and bioactivity of selected metal complexes with imine ligands

Snježana Marić orcid id orcid.org/0000-0001-6451-7402 ; Faculty of Natural Sciences and Mathematics, University of Tuzla, Urfeta Vejzagića 4, 75000 Tuzla, Bosnia and Herzegovina
Nusreta Hasić ; Faculty of Natural Sciences and Mathematics, University of Tuzla, Urfeta Vejzagića 4, 75000 Tuzla, Bosnia and Herzegovina
Emir Horozić orcid id orcid.org/0000-0003-0242-3093 ; Faculty of Technology, University of Tuzla, Urfeta Vejzagića 8, 75000 Tuzla, Bosnia and Herzegovina
Amira Cipurković orcid id orcid.org/0000-0002-4801-8870 ; Faculty of Natural Sciences and Mathematics, University of Tuzla, Urfeta Vejzagića 4, 75000 Tuzla, Bosnia and Herzegovina
Aleksandar Antić orcid id orcid.org/0000-0001-6451-7402 ; Faculty of Pharmacy, University of Tuzla, Urfeta Vejzagića 8, 75000 Tuzla, Bosnia and Herzegovina
Zerina Mujić ; Faculty of Pharmacy, University of Tuzla, Urfeta Vejzagića 8, 75000 Tuzla, Bosnia and Herzegovina
Karla Pelemiš ; Faculty of Pharmacy, University of Tuzla, Urfeta Vejzagića 8, 75000 Tuzla, Bosnia and Herzegovina
Kenan Brkić ; Faculty of Pharmacy, University of Tuzla, Urfeta Vejzagića 8, 75000 Tuzla, Bosnia and Herzegovina
Demir Bjelošević ; Faculty of Pharmacy, University of Tuzla, Urfeta Vejzagića 8, 75000 Tuzla, Bosnia and Herzegovina

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Abstract

The chemistry of complex compounds containing imine ligands is attracting significant attention from researchers today. In this work, complexes of selected transition metals (Cu, Co, Ni and Fe) with imines based on ninhydrin and amino acids methionine and cysteine were synthesized. FTIR and UV/VIS spectroscopy were used for structural characterization. Antioxidant activity of the complex was analyzed by the FRAP method. The synthesized compounds showed a significant reducing ability, ranging from 221.94 to 756.30 µmol/L. In vitro antimicrobial activity was tested on strains from the ATCC collection. Inhibitory activity against the tested microorganisms was recorded, and the zones of inhibition ranged from 10-24 mm. Preliminary research shows that these compounds have biological potency, but more detailed in vitro and in vivo studies are required for their use.

Keywords

metal complexes; imine; bioactivity; antibacterial agents; FRAP

Hrčak ID:

252361

URI

https://hrcak.srce.hr/252361

Publication date:

31.12.2020.

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