Original scientific paper
https://doi.org/10.15255/KUI.2020.056
Optimisation of the Microencapsulation of an Active Ingredient by Crosslinking and the Coating Method to Target Colon Diseases
Mounir Hammoudi
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Yahia Fares University, Department of Chemical Engineering and Environment, Experimental Biology and Pharmacology Team, Médéa, 26 000, Algeria
Djamel Atsamnia
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Équipe Biologie et Pharmacologie exprémentales, Yahia Fares University, Médéa, 26 000, Algeria
Khaled Otmanine
; Bio-ressources Naturelles Locales LBRN, Chlef University, Faculty of Technology, Department of Process Engineering, Chlef, Algeria
Riadh Moumen
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Équipe Biologie et Pharmacologie exprémentales, Yahia Fares University, Médéa, 26 000, Algeria
Mustapha Oumouna
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Yahia Fares University, Department of Chemical Engineering and Environment, Experimental Biology and Pharmacology Team, Médéa, 26 000, Algeria
Abstract
The aim of this study was to prepare microcapsules based on a natural polymer chitosan solution (high degree of deacetylation (DDA), low molecular weight (MW), and low viscosity)/sodium alginate in the presence of a crosslinking agent (glutaraldehyde), in order to encapsulate and vectorise the active principle towards the diseased organ (colon), without being diffused into other levels of the digestive tract, to increase the therapeutic effectiveness of treatment by chemotherapy and to reduce undesirable effects. The method of preparation of the microcapsules obtained from the sodium alginate/chitosan solution/active ingredients system was examined by conventional optical microscopy. In addition, an in vitro study was carried out on the active ingredients’ release profiles, depending on the pH simulating the gastric and intestinal media for the seven systems proposed. It should be mentioned that, in the basic medium (pH(colon) = 8), the release of the active ingredients is of the utmost importance. Nevertheless, control of this release can be improved by a crosslinking agent and the coating method. The dry [sodium alginate / chitosan solution / active ingredients + crosslinking 2 %] formulation coated with non-crosslinked chitosan (Formulation 7) is the standard formula that meets all the criteria from our earlier work, with a core release rate of 67 %. The PSD was unimodal, with sizes ranging from 750 µm to 900 µm.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Keywords
microcapsules; colon diseases; alginate; chitosan; vectorisation; coating; crosslinking
Hrčak ID:
257555
URI
Publication date:
18.5.2021.
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