Original scientific paper
https://doi.org/10.15255/KUI.2020.062
Preventive Activity of Giner (Zingiber officinale) Against Myelotoxicity and Hepatotoxicity Induced by Cyclohexatriene and Identification of the Most Active Compounds by GC-MS
Khaled Otmanine
; Bioressources Naturelles Locales (LBRN) Laboratory, Hassiba Benbouali University of Chlef, Faculty of Technology Department of Process Engineering, 02000 Chlef, Algeria
Salah Hanini
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Yahia Fares University, Department of Chemical Engineering and Environment, Médéa, 26 000, Algeria
Othmane Benkortbi
orcid.org/0000-0002-1965-7171
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Yahia Fares University, Department of Chemical Engineering and Environment, Médéa, 26 000, Algeria
Razika Bekri
; Laboratory of Haematology, Mohamed Boudiaf Hospital, Médéa, Algeria
Karim Amroun
; Laboratory of Pathological Anatomy, Mohamed Boudiaf Hospital, Médéa, Algeria
Merouane Djellal
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Equipe Biologie et Pharmacologie Experimentale, Yahia Fares University, Department of Nature and Life Sciences, Faculty of Sciences, Médéa, 26 000, Algeria
Sara Kohli
; Bioressources Naturelles Locales (LBRN) Laboratory, Hassiba Benbouali University of Chlef, Faculty of Technology Department of Process Engineering, 02000 Chlef, Algeria
Karine Oumouna-Benachour
; Biomaterials and Transport Phenomena Laboratory (LBMPT), Equipe Biologie et Pharmacologie Experimentale, Yahia Fares University, Department of Nature and Life Sciences, Faculty of Sciences, Médéa, 26 000, Algeria
Abstract
This study aimed to uncover the preventive capability of Zingiber officinale against myelotoxicity, leukaemia, and hepatotoxicity. For the most part, this work depended on the subcutaneous injection of cyclohexatriene in rabbits to cause the illness by a synthetic strategy. In parallel, another group of rabbits was exposed to the injection of cyclohexatriene under similar conditions with the feeding Zingiber officinale, where it was discovered that the cyclohexatriene-induced myelotoxicity was counteracted. The histological examination additionally uncovered the hepato-defensive intensity of Zingiber officinale. The most pharmacologically active molecules of Zingiber officinale were recognised by gas chromatography–mass spectrometry (GC-MS).
Keywords
Zingiber officinale; hepato-protective activity; cyclohexatriene; myelotoxicity; GC-MS
Hrčak ID:
259338
URI
Publication date:
24.6.2021.
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