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Chemistry in Industry : Journal of Chemists and Chemical Engineers of Croatia, Vol. 70 No. 7-8, 2021.

Original scientific paper

https://doi.org/10.15255/KUI.2020.062

Preventivna aktivnost đumbira (Zingiber officinale) u suzbijanju mijelotoksičnosti i hepatotoksičnosti izazvane cikloheksatrienom i identifikacija najaktivnijih spojeva metodom GC-MS

Khaled Otmanine ; Bioressources Naturelles Locales (LBRN) Laboratory, Hassiba Benbouali University of Chlef, Faculty of Technology Department of Process Engineering, 02000 Chlef, Algeria
Salah Hanini ; Biomaterials and Transport Phenomena Laboratory (LBMPT), Yahia Fares University, Department of Chemical Engineering and Environment, Médéa, 26 000, Algeria
Othmane Benkortbi orcid id orcid.org/0000-0002-1965-7171 ; Biomaterials and Transport Phenomena Laboratory (LBMPT), Yahia Fares University, Department of Chemical Engineering and Environment, Médéa, 26 000, Algeria
Razika Bekri ; Laboratory of Haematology, Mohamed Boudiaf Hospital, Médéa, Algeria
Karim Amroun ; Laboratory of Pathological Anatomy, Mohamed Boudiaf Hospital, Médéa, Algeria
Merouane Djellal ; Biomaterials and Transport Phenomena Laboratory (LBMPT), Equipe Biologie et Pharmacologie Experimentale, Yahia Fares University, Department of Nature and Life Sciences, Faculty of Sciences, Médéa, 26 000, Algeria
Sara Kohli ; Bioressources Naturelles Locales (LBRN) Laboratory, Hassiba Benbouali University of Chlef, Faculty of Technology Department of Process Engineering, 02000 Chlef, Algeria
Karine Oumouna-Benachour ; Biomaterials and Transport Phenomena Laboratory (LBMPT), Equipe Biologie et Pharmacologie Experimentale, Yahia Fares University, Department of Nature and Life Sciences, Faculty of Sciences, Médéa, 26 000, Algeria

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Abstract

Cilj ove studije bio je otkriti preventivnu sposobnost Zingiber officinale u suzbijanju mijelotoksičnosti, leukemije i hepatotoksičnosti. Ovaj je rad većim dijelom temeljen na potkožnom ubrizgavanju cikloheksatriena u kuniće da bi se sintetskom strategijom izazvala bolest. Usporedno s time, druga skupina kunića bila je izložena injekciji cikloheksatriena u sličnim uvjetima s hranjenjem Zingiber officinale, gdje je otkriveno da je suprotstavljena mijelotoksičnost izazvana cikloheksatrienom. Histološkim pregledom dodatno je otkriven hepatoprotektivni intenzitet Zingiber officinale. Najviše farmakološki aktivnih molekula Zingiber officinale prepoznato je metodom plinske kromatografije–masene spektrometrije (GC-MS).

Keywords

Zingiber officinale; hepatoprotektivno djelovanje; cikloheksatrien; mijelotoksičnost; GC-MS

Hrčak ID:

259338

URI

https://hrcak.srce.hr/259338

Publication date:

24.6.2021.

Article data in other languages: english

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