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Acta clinica Croatica, Vol. 60. No. Supplement 1, 2021.

Original scientific paper

https://doi.org/10.20471/acc.2021.60.s1.06

Free Thyroxine and Triiodothyronine are Associated with Renal Function in Normoalbuminuric Euthyroid Type 1 Diabetic Patients

Tomislav Bulum orcid id orcid.org/0000-0003-4808-2968 ; Vuk Vrhovac Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital, Zagreb, Croatia; Medical School, University of Zagreb, Zagreb, Croatia
Marijana Vučić Lovrenčić ; Clinical Department of Medical Biochemistry and Laboratory Medicine, Merkur University Hospital, Zagreb, Croatia
Ingrid Prkačin orcid id orcid.org/0000-0002-5830-7131 ; Medical School, University of Zagreb, Zagreb, Croatia; Department of Internal Medicine, Merkur University Hospital, Zagreb, Croatia
Lea Duvnjak ; Vuk Vrhovac Clinic for Diabetes, Endocrinology and Metabolic Diseases, Merkur University Hospital, Zagreb, Croatia; Medical School, University of Zagreb, Zagreb, Croatia

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Abstract

Both hypothyroidism and hyperthyroidism affect renal function. The aim of this
study was to investigate the relationship between parameters of thyroid function (TSH, free triiodothyronine
(FT3), and free thyroxine (FT4)) and parameters of renal function in patients with type 1
diabetes (T1DM). The study included 272 T1DM with normoalbuminuria and estimated glomerular
filtration rate (eGFR) > 60 ml/min-11.73m-2, normal thyroid function, and without antihypertensive
and antihyperlipidemic therapy. TSH significantly correlated with urinary albumin excretion rate
(UAE) (r=-0.15, p<0.05) and fT3 with serum creatinine (r=0.12, p<0.05). Furthermore, fT4 significantly
correlated with all renal function parameters (serum creatinine, eGFR and UAE (r=-0.12, 0.34
and -0.13, respectively, for all p<0.05)). Patients in the highest quartile of fT4 had significantly higher
eGFR levels compared to those in the lowest quartile (116 vs. 101 ml/min-11.73m-2, p<0.001). In logistic
regression analysis, after adjustment for covariates, fT3 and fT4 were significantly associated
with worsening of renal function parameters with odds ratios of 0.75 to 1.29. This study, conducted in
euthyroid T1DM with normoalbuminuria and eGFR > 60 ml/min-11.73m-2 without therapeutic intervention,
suggests that the thyroid function may be connected with renal function parameters even
in the euthyroid range.

Keywords

Thyroid hormones; Type 1 diabetes; Renal function; Albuminuria

Hrčak ID:

260293

URI

https://hrcak.srce.hr/260293

Publication date:

1.1.2021.

Article data in other languages: croatian

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