Case report

https://doi.org/10.20471/acc.2021.60.s1.18

Tiopronin and/or NSAID? A Case of Nephrotic Syndrome and Acute Interstitial Nephritis in a Young Woman with Cystinuria.

Luka Vidović ; Division of Nephrology, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Josipa Josipović ; Division of Nephrology, Department of Internal Medicine, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Petar Šenjug
Danica Galešić Ljubanović ; Department of Pathology, University Hospital Dubrava, Zagreb

Abstract

Cystinuria is an autosomal recessive disease that leads to recurrent stone formation.
Tiopronin, a glycine derivative with a free thiol similar to penicillamine, prevents stone formation
and facilitates their dissolution. Nephrotic-range proteinuria is a serious and relatively uncommon
adverse effect, reported in 6-10% of patients, most frequently during the first year of tiopronin use.
Various patterns of morphologic kidney injury have been associated with tiopronin use, including
MCD, MN, and MPGN. Acute interstitial nephritis can be caused virtually by any drug. Non-steroidal
anti-inflammatory drugs (NSAID s) may cause AIN , with or without nephrotic syndrome due to
minimal change disease or membranous nephropathy.

Keywords

Tiopronin; NSAID; Acute interstitial nephritis

Hrčak ID:

260414

URI

https://hrcak.srce.hr/260414

Publication date:

1.1.2021.

Article data in other languages: croatian

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