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Chemistry in Industry : Journal of Chemists and Chemical Engineers of Croatia, Vol. 71 No. 3-4, 2022.

Original scientific paper

https://doi.org/10.15255/KUI.2021.035

Comparative Therapeutic Properties of Garlic Extract and Metformin on Hyperglycaemia, Hypercholesterolaemia, and Hypertriglyceridaemia in Alloxan-induced Type1-like Diabetic Rats

Djamel Atsamnia ; Biomaterials and Transport Phenomena Laboratory (LBMPT), Dr Yahia Fares University of Médéa, Algeria
Salah Hanini ; Biomaterials and Transport Phenomena Laboratory (LBMPT), Dr Yahia Fares University of Médéa, Algeria
Dahmane Oukrif orcid id orcid.org/0000-0001-8645-158X ; University College London, Department of Pathology, UK
Karine Benachour ; Laboratory of Experimental Biology and Pharmacology, Faculty of Sciences, Dr Yahia Fares University of Médéa, Algeria
Othmane Benkortbi orcid id orcid.org/0000-0002-1965-7171 ; Biomaterials and Transport Phenomena Laboratory (LBMPT), Dr Yahia Fares University of Médéa, Algeria
Mabrouk Hamadache ; Biomaterials and Transport Phenomena Laboratory (LBMPT), Dr Yahia Fares University of Médéa, Algeria

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Abstract

The current pilot study was conducted to compare the triple effect of garlic extract and metformin on hyperglycaemia, hypercholesterolaemia, and hypertriglyceridaemia in alloxan-induced type 1-like diabetic rats. Wistar rats were randomly divided into four groups. Control group included normal rats. The second group included alloxan-induced type 1-like diabetic rats, receiving no treatment. The other two groups of diabetic rats were orally treated with 0.75 g of garlic extract per kg of body weight and 0.05 of metformin g per kg of body weight respectively for four weeks. The pharmacological impact of garlic compounds on serum glucose and lipids as opposed to the glucose-lowering and lipid-lowering was highlighted in these experiments. These results revealed that garlic extract has a triple action on hyperglycaemia, hypertriglyceridemia, and hypercholesterolemia. Its effect on hyperglycaemia is long lasting, and more pronounced compared to the metformin. Interestingly, it had a regulatory effect on glycaemia as highlighted in the control group.




This work is licensed under a Creative Commons Attribution 4.0 International License.

Keywords

alloxan; diabetes; garlic extract; glycaemia; metformin

Hrčak ID:

274065

URI

https://hrcak.srce.hr/274065

Publication date:

16.3.2022.

Article data in other languages: croatian

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