Original scientific paper

https://doi.org/10.20471/acc.2021.60.04.09

Surgical and Seizure Treatment Outcomes in Adult Dysembryoplastic Neuroepithelial Tumors: a Case Series

Tomislav Sajko ; Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia; Department of Anatomy, University of Applied Health Sciences, Zagreb, Croatia
Krešimir Rotim ; Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia; Department of Anatomy, University of Applied Health Sciences, Zagreb, Croatia
Mia Jurilj ; Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Anatomy, University of Applied Health Sciences, Zagreb, Croatia
Ante Rotim ; Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Department of Anatomy, University of Applied Health Sciences, Zagreb, Croatia
Bruno Splavski ; Department of Neurosurgery, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Josip Juraj Strossmayer University of Osijek, Faculty of Medicine, Osijek, Croatia; Department of Anatomy, University of Applied Health Sciences, Zagreb, Croatia; Josip Juraj Strossmayer University of Osijek, School of Dental Medicine and Health, Osijek, Croatia
Ivana Jurčić Čulina ; University of Applied Health Sciences, Zagreb, Croatia

Abstract

Dysembryoplastic neuroepithelial tumors (DNETs) are benign neoplasms classified
in the category of glioneuronal tumors. The estimated incidence of DNETs is 0.03 per 100,000
person per year with the age peak in a range between 10 and 14 years, and decreasing dramatically with
increasing age. They are seldom diagnosed in persons above 20 years of age, being a cause of tumorrelated
intractable epilepsy that begins in childhood or adolescence. They have been proven to be the
second most common type of epileptogenic tumors in pediatric population. These rare tumors cause
chronic drug-resistant partial complex seizures with or without secondary generalization. Herein, we
provide institutional case series of six adult patients with temporal lobe DNET presenting with complex
partial seizures. Lesionectomy was performed with tumor resection in toto in three patients. In
another three, partial resection was performed, whereas tumor remnant was left intact to avoid possible
basal ganglia damage. All patients were seizure free postoperatively. Lesionectomy alone in temporal
lobe epilepsy was associated with less favorable outcome than anterior temporal lobectomy. Total
tumor removal is considered a major prognostic factor in most studies.

Keywords

Dysembryoplastic neuroepithelial tumor; Seizure; Surgery; Outcome

Hrčak ID:

275494

URI

https://hrcak.srce.hr/275494

Publication date:

1.12.2021.

Article data in other languages: croatian

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