Original scientific paper
Significance of histopathologic criteria in survival rates of patients with colorectal cancer: multivariate analysis
Siniša Maksimović
; General Hospital “Sveti Vracevi” in Bijeljina, Bosnia and Herzegovina
Abstract
Background: Risk factors predicting the presence of lymph node metastasis have not been fully investigated. To determine the criteria for local excision of colorectal cancer, histopathologic factors independently predicting the lymph node metastasis were investigated. Methods: We performed a retrospective histological study on 301 patients who underwent resection of colorectal cancer and dissection of regional lymph nodes between January1, 2000 to December 31, 2007. Results: In multivariate analysis when we compared patients who have been less than 3 node metastases (n=165) with patients who have been 4 and more than node metastases (n=136) were characterized by tumor larger than 60 mm (28% vs. 0%), serosal invasion (46% vs. 19%), venous invasion (33% vs. 21%), histologic grade II -III (62% vs.28%). Multivariate analysis showed that factors independently associated with lymph node metastasis were serosal invasion, venous invasion and histologic grade. When these three risk factors were negative, lymph node metastasis was rare (5%). When one, two or three factors were negative, lymph node metastasis was 38%, 66% i 85% respectively. Conclusions: Factors independently associated with lymph node metastasis are serosal invasion, venous invasion and histologic grade. When these three factors are favorable, local tretmen of colorectal cancer does not require additional lymph node dissection.
Keywords
multivariate analysis; histopathologic criteria
Hrčak ID:
279198
URI
Publication date:
27.11.2008.
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