Review article

New trends in the treatment of myeloid malignancies

Labar Boris ; Division of Hematology, Department of Medicine, Medical School, University of Zagreb and Clinical Hospital Center, Zagreb, Croatia

Abstract

Molecular defects discovered in the recent years could explain the pathogenesis of myeloid malignancies. Moreover these alterations serve as the targets for the therapy. In this article treatment approach of myeloid malignancies is presented, together with the new treatment possibilities specifically acting on the level of molecular defects. Therapy with the combination of several agents which target more than one molecular alterations i.e. gene mutation, signal transduction pathway or antigenic determinant may be the most promising therapy in the future.

Keywords

myeloproliferative disorders; AML; CML; MDS; molecular defects; targeted therapy

Hrčak ID:

281500

URI

https://hrcak.srce.hr/281500

Publication date:

7.12.2006.

Article data in other languages: croatian

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