Original scientific paper
Pilot study of the therapeutic effect of „Excipial U Lipolotion“ emulsion in radiotherapy patients with inflammatory skin reaction
Hrvoje Kaučić
; Department of Radiation Oncology, University Hospital for Tumors, Zagreb, Croatia
Tonko Herceg
; Department of Radiation Oncology, University Hospital for Tumors, Zagreb, Croatia
Dinko Čović
; Department of Radiation Oncology, University Hospital for Tumors, Zagreb, Croatia
Katarina Antunac
; Department of Radiation Oncology, University Hospital for Tumors, Zagreb, Croatia
Meliha Solak
; Department of Radiation Oncology, University Hospital for Tumors, Zagreb, Croatia
Mirko Šamija
; Department of Radiation Oncology, University Hospital for Tumors, Zagreb, Croatia
Abstract
During radiotherapy, inflammatory skin reaction develops to a lesser or greater extent in almost every patient. Transdermal moisture loss - skin dehydration, as one of the effects of irradiation, is favorable for the onset of inflammatory skin reactions, it enhances the symptoms and retards skin recovery. Excipial U Lipolotion, W/O emulsion with a 4% urea segment rehydrates the skin and decreases the transdermal moisture loss. In the past clinical studies, preparations with a 3-4% urea segment have proved to be efficient means of treating the inflammatory skin reactions.
Based on that, we have conduced a study applying the Excipial U Lipolotion preparation on the skin of radiotherapy patients with explicit inflammatory skin reactions. Patients with head and neck cancers as well as breast cancer were included. The preparation's efficiency was evaluated upon a clinical review of the skin condition's subjective parameters by the physician and by questioning the patient whether or not the preparation was useful. We came to a conclusion that Excipial U Lipolotion has a favorable effect on the inflammatory skin reactions with a very distinct effect on the dry inflammatory reactions. It also decreases subjective problems - irritation, burning, pain - to a greater extent in radiotherapy patients. Regarding the fact that the evaluation parameters were subjective, further research of the Excipial U Lipolotion effect is required, based on objective clinical indications - skin moisture degree during the preparation's application.
Keywords
inflammatory skin reactions; Excipial U Lipolotion; radiotherapy; transdermal moisture loss
Hrčak ID:
281797
URI
Publication date:
3.12.2003.
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