Review article

https://doi.org/10.2478/acph-2023-0001

Recent approaches in the drug research and development of novel antimalarial drugs with new targets

NAVEEN KUMAR REDDY CHINNAPPANNA ; Shri Vishnu College of Pharmacy, B.V Raju group of Institutions, Vishnupur, Bhimavaram West Godavari District, Andhra Pradesh 534202, India
GOPI YENNAM ; Shri Vishnu College of Pharmacy, B.V Raju group of Institutions, Vishnupur, Bhimavaram West Godavari District, Andhra Pradesh 534202, India
CHAITANYA BUDAGAM HAIMA NAGA VENKATA CHAITANYA ; Shri Vishnu College of Pharmacy, B.V Raju group of Institutions, Vishnupur, Bhimavaram West Godavari District, Andhra Pradesh 534202, India
SHINU POTTATHIL orcid.org/0000-0003-4245-0803 ; Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University Al-Ahsa 31982, Kingdom of Saudi Arabia
POBITRA BORAH ; School of Pharmacy, Graphic Era Hill University, Dehradun 248002, Uttarakhand, India
KATHARIGATTA N. VENUGOPALA ; Department of Biotechnology and Food Science, Faculty of Applied Sciences Durban University of Technology, Durban, 4000, South Africa; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University Al-Ahsa 31982, Saudi Arabia
PRAN KISHORE DEB orcid.org/0000-0002-8650-2874 ; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University, Amman19392, Jordan
RAGHU PRASAD MAILAVARAM orcid.org/0000-0001-6126-5860 ; Department of Pharmaceutical Chemistry, Shri Ville Parle Kelavani Mandal's Institute of Pharmacy, Survey No. 499, Plot No 03, Mumbai – Agra National Hwy, Behind Gurudwara, Samta Nagar, Dhule, Maharashtra 424001

Abstract

Malaria is a serious worldwide medical issue that results in substantial annual death and morbidity. The availability of treatment alternatives is limited, and the rise of resistant parasite types has posed a significant challenge to malaria treatment. To prevent a public health disaster, novel antimalarial agents with single-dosage therapies, extensive curative capability, and new mechanisms are urgently needed. There are several approaches to developing antimalarial drugs, ranging from alterations of current drugs to the creation of new compounds with specific targeting abilities. The availability of multiple genomic techniques, as well as recent advancements in parasite biology, provides a varied collection of possible targets for the development of novel treatments. A number of promising pharmacological interference targets have been uncovered in modern times. As a result, our review concentrates on the most current scientific and technical progress in the innovation of new antimalarial medications. The protein kinases, choline transport inhibitors, dihydroorotate dehydrogenase inhibitors, isoprenoid biosynthesis inhibitors, and enzymes involved in the metabolism of lipids and replication of deoxyribonucleic acid, are among the most fascinating antimalarial target proteins presently being investigated. The new cellular targets and drugs which can inhibit malaria and their development techniques are summarised in this study.

Keywords

antimalarial drugs; protein kinases; dihydroorotate dehydrogenase

Hrčak ID:

283821

URI

https://hrcak.srce.hr/283821

Publication date:

31.3.2023.

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