Original scientific paper

https://doi.org/10.20471/acc.2022.61.02.08

Učinkovitost dijete za snižavanje lipida na ključne omjere masnih kiselina i omega-3 indeks kod osoba s hiperlipidemijama

Danijela Ristić-Medić orcid.org/0000-0002-7041-4220 ; Group for Nutritional Biochemistry and Dietology, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
Snježana Petrović orcid.org/0000-0002-1387-9777 ; Group for Nutritional Biochemistry and Dietology, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
Marija Takić ; Group for Nutrition and Metabolism, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
Vesna Vučić orcid.org/0000-0002-8563-594X ; Group for Nutritional Biochemistry and Dietology, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
Aleksandra Arsić ; Group for Nutritional Biochemistry and Dietology, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia
Slavica Rađen ; Faculty of Medicine, Military Medical Academy, University of Defense, Belgrade, Serbia
Marija Glibetić ; Group for Nutrition and Metabolism, Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia

Abstract

Prehrambeni unos polinezasićenih masnih kiselina (MK), status i ključni omjeri MK u serumu mogu biti od pomoći
u procjeni rizika za kardiovaskularne bolesti. Cilj ove studije bio je istražiti učinke prehrane koja snižava lipide na ključne
omjere MK u fosfolipidima (FL) seruma i omega-3 indeks u FL eritrocita kod osoba s umjerenom hiperlipidemijom. U
istraživanju je sudjelovala 41 osoba prosječne dobi 56±6 godina. Prehrambene navike ocjenjivane su upitnikom o učestalosti
konzumiranja hrane. Sudionici su 12 tjedana bili na dijeti. Unos energije iz omega-6 i omega-3 MK promijenjen je sa
7,6% i 0,6% na 5,7% i 1,2%. Nakon dijete smanjeni su omjeri MK u FL seruma: omega-6/omega-3, arahidonska kiselina
(AA)/eikosapentaenska kiselina (EPA), AA/dokozaheksaenoinska kiselina (DHA), AA/(EPA+DHA) i omega-3 indeks
(EPA+DHA). Omjer ukupnog kolesterola/HDL-a, LDL/HDL-a i triacilglicerola/HDL-kolesterola pozitivno je korelirao
sa svim omjerima MK, a negativno s ukupnim razinama omega-3 u FL seruma i omega-3 indeksom u eritrocitima. Ukupne
omega-3 u serumu pokazale su značajnu povezanost s omjerima lipoproteina i pozitivnu koleraciju s indeksom HOMA.
U zaključku, dijeta sa smanjenim unosom lipida dovela je do smanjenja ključnih omjera MK u serumu, povišenja razine
omega-3 i poboljšanja osjetljivosti na inzulin, što može dovesti do nižeg rizika za kardiovaskularne bolesti kod osoba s
umjerenom hiperlipidemijom.

Keywords

Omjer masnih kiselina; Hiperlipidemija; Dijeta za snižavanje lipida; Omega-3 indeks; TG/HDL

Hrčak ID:

284688

URI

https://hrcak.srce.hr/284688

Publication date:

1.8.2022.

Article data in other languages: english

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