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Acta clinica Croatica, Vol. 61. No. 2, 2022.

Review article

https://doi.org/10.20471/acc.2022.61.02.18

Clinical Course of the Disease and Treatment Outcome in Patients with Malignant Laryngeal Tumor: Retrospective Five-Year Analysis

Jelena Vukelić orcid id orcid.org/0000-0001-5828-9087 ; Department of Otolaryngology and Head and Neck Surgery, Rijeka University Hospital Center, Rijeka, Croatia; Faculty of Health Studies, Clinical Sciences, Rijeka, Croatia
Renata Dobrila-Dintinjana ; Department of Radiotherapy and Oncology, Rijeka University Hospital Center, Rijeka, Croatia
Blažen Marijić orcid id orcid.org/0000-0001-6094-7114 ; Department of Otolaryngology and Head and Neck Surgery, Rijeka University Hospital Center, Rijeka, Croatia
Diana Maržić ; Audiology and Phoniatrics Unit, Rijeka University Hospital Center, Rijeka, Croatia
Tamara Braut ; Department of Otolaryngology and Head and Neck Surgery, Rijeka University Hospital Center, Rijeka, Croatia

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Abstract

The aim was to investigate clinical course of disease in patients with malignant
laryngeal tumors with emphasis on various forms of disease recurrence (local recurrence, metastasis
to regional lymph nodes, occurrence of second primary tumor). A retrospective research including
78 patients with histopathologically confirmed diagnosis of squamous cell laryngeal carcinoma was
conducted. Information on cancer stage, histologic grade, type of treatment and disease recurrence
was obtained from medical history. Tissue samples of the patients were submitted to immunohistochemical
analysis and assessment of Ki-67 proliferation index expression. The occurrence of second
primary tumor was found to be related to the significantly higher Ki-67 proliferation index. The number
of patients having not undergone oncologic therapy and remained free from disease recurrence
was significantly higher than expected. Treatment outcome depends on patient age, histologic grade,
radiotherapy applied, and clinical course of disease. It is necessary to define the predictive factors of
various forms of disease recurrence more precisely in order to identify better treatment options for
patients with malignant tumors of the larynx.

Keywords

Laryngeal cancer; Treatment outcome; Local recurrence; Second primary tumor

Hrčak ID:

285011

URI

https://hrcak.srce.hr/285011

Publication date:

1.8.2022.

Article data in other languages: croatian

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