Review article

https://doi.org/10.15255/KUI.2022.027

Pharmaceutical Significance of the Stereoisomerisation Process

Lucija Hok orcid.org/0000-0003-0731-1293 ; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Laboratory for the Computational Design and Synthesis of Functional Materials, Bijenička cesta 54, 10 000, Zagreb, Croatia
Davor Šakić orcid.org/0000-0002-8871-6622 ; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Analytical Chemistry, Ul. Ante Kovačića 1, 10 000 Zagreb, Croatia
Valerije Vrček orcid.org/0000-0003-1624-8126 ; University of Zagreb, Faculty of Pharmacy and Biochemistry, Department of Organic Chemistry, Ul. Ante Kovačića 1, 10 000 Zagreb, Croatia
Robert Vianello orcid.org/0000-0003-1779-4524 ; Ruđer Bošković Institute, Division of Organic Chemistry and Biochemistry, Laboratory for the Computational Design and Synthesis of Functional Materials, Bijenička cesta 54, 10 000, Zagreb, Croatia

Abstract

Investigation of the stereoisomerisation process is of the utmost importance in pharmaceutical chemistry and biomedicine. Different isomers can exhibit significant differences when interacting with biological macromolecules, which may result in their modified pharmacokinetic and pharmacodynamic properties, thereby showing different therapeutic and undesirable effects. Although there are numerous examples illustrating the importance of stereochemistry, this article presents an overview of the most significant and representative cases in pharmacy.

Keywords

stereoisomers; configurational instability; pharmacological and pharmaceutical time scales; chiral drugs

Hrčak ID:

291082

URI

https://hrcak.srce.hr/291082

Publication date:

11.1.2023.

Article data in other languages: croatian

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