Original scientific paper
Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker
Elvira Mustać
Gordana Zamolo
Marija Petković
Gordana Đorđević
Jelena Radić
Emina Grgurević
Tanja Batinac
Abstract
The aim of this study was to analyse breast carcinomas with discordant receptor status, probably hormonal dependent
(estrogen receptor (ER) positive, progesterone receptor (PR) negative or ER-PR+ subgroup profile) infiltrating ductal
breast carcinomas not otherwise specified (IDC NOS). Specimens from 90 IDC NOS were grouped into three categories
according to hormonal status: dependent (D) (ER+PR+), probably dependent (PD) (ER+PR- or ER-PR+) and non-dependent
(ND) (ER-PR-); they were evaluated considering some established prognostic parameters in breast carcinomas.
Statistically significant difference was found between tumor receptor status distribution and menopausal status (p=
0.0235), age of the patients (p=0.000467), histological grade (p=0.000003), vascular invasion (p=0.006), HER-2 status
(p=0.0039) and Ki-67 proliferation rate (p=0.000311). D tumors were found exclusively in post-menopausal patients
(average age 68.9 years), most of which had intermediate (II) grade, without vascular invasion, with HER-2 status score
predominantly 0 or 1+ and lower Ki-67 proliferation rate. PD tumors were found predominantly in younger post-menopausal
patients (average age 57.5 years), with vascular invasion found in 23% of the cases. ND tumors mostly had higher
histological grade, showed the highest percentage of the Ki-67 positive tumor cells and vascular invasion in 30% of the
cases. We conclude that the patients with PD breast carcinomas were younger post-menopausal women with the tumors
moderately differentiated, HER-2 score 0 or 1+ and with lower Ki-67 proliferation rate.
Keywords
breast carcinoma; hormone receptors; menopausal status; HER-2; Ki-67
Hrčak ID:
27056
URI
Publication date:
2.9.2008.
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