Review article

https://doi.org/10.2478/acph-2023-0014

Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities

SIJIA FAN ; Department of Intensive Care Unit, South China Hospital, Health Science Center, Shenzhen University Guangdong, Shenzhen, 518116, P. R. China
HONGLING WANG ; Department of Cardiothoracic Surgery, 940th Hospital of Joint Logistic Support Force of PLA, Lanzhou, Gansu, 730050, P. R. China
DEAN WU ; Department of Respiratory Medicine, The Third People's Hospital of Gansu Province, Lanzhou University, Lanzhou, Gansu, 730050, P. R. China
LU LIU ; The First Pulmonary and Critical Care Medicine, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110032, P. R. China

Abstract

SARS-CoV-2, a newly discovered coronavirus, has been linked to the COVID-19 pandemic and is currently an important public health issue. Despite all the work done to date around the world, there is still no viable treatment for COVID-19. This study examined the most recent evidence on the efficacy and safety of several therapeutic options available including natural substances, synthetic drugs and vaccines in the treatment of COVID-19. Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. We attempted to provide exhaustive information regarding the various prospective therapeutic approaches available in order to assist researchers and physicians in treating COVID-19 patients.

Keywords

COVID-19; SARS-CoV-2; drugs; natural compounds; vaccine; treatment

Hrčak ID:

303171

URI

https://hrcak.srce.hr/303171

Publication date:

30.6.2023.

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