Croatica Chemica Acta, Vol. 95 No. 4, 2022.
Original scientific paper
https://doi.org/10.5562/cca3936
Ternary Coordination Compounds of Copper(II) with Glycine and 2,2'-bipyridine: Synthesis, Structural Characterization, Magnetic and Biological Properties
Darko Vušak
; Division of General and Inorganic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000, Zagreb, Croatia
Katarina Mišković Špoljarić
; Department of Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia
Jurica Jurec
; Laboratory for Magnetic Resonances, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia
Dijana Žilić
; Laboratory for Magnetic Resonances, Division of Physical Chemistry, Ruđer Bošković Institute, Bijenička cesta 54, HR-10000 Zagreb, Croatia
Biserka Prugovečki
; Division of General and Inorganic Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, HR-10000, Zagreb, Croatia
Supplements: cca3936-supplement.pdf
Abstract
Three new coordination compounds of copper(II) with glycine (HGly) and 2,2'-bipyridine (bipy) were synthesized by solution-based and mechanochemical methods: [Cu(Gly)(H2O)(bipy)][Cu(Gly)(SO4)(bipy)]·6H2O (1a·6H2O), [Cu(Gly)(H2O)(bipy)]2SO4 (1b), [Cu(Gly)(H2O) (bipy)]2SO4·H2O (1b·H2O). The amount of water in the reaction mixture influenced the product of crystallization. All compounds were characterized by X-ray diffraction methods and form 1D infinite chains or 2D sheets of complex ions connected by π-interactions. Compounds 1a·6H2O and 1b were characterized by X-band electron spin resonance (ESR) spectroscopy and the values of g-tensors for Cu(II) ions were determined. Compounds 1a·6H2O and 1b showed pronounced antiproliferative activity toward a panel of six human cell lines. The most impared was HepG2 cell line at 10−5 mol dm−3 concentration (74.5 % reduction of cell growth) followed by moderate activity toward KATO III, Caco-2, MDA-MB-231, PANC-1 and MRC-5 cells at 10−4 mol dm−3 concentration of compounds 1a·6H2O and 1b. Generally, both compounds express similar antiproliferative effect on evaluated cells.
Keywords
X-ray diffraction; ESR spectroscopy; crystallization; mechanochemistry; ternary coordination compounds; copper(II); glycine; carcinoma; tumor cell lines
Hrčak ID:
305722
URI
Publication date:
5.7.2023.
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