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Croatica Chemica Acta, Vol. 96 No. 2, 2023.

Original scientific paper

https://doi.org/10.5562/cca4001

Ecofriendly Synthesis of DHPMs using Copper-based Nano catalysts and Evaluation of Antibacterial Activity

Khushboo Sharma ; Department of chemistry, University of Rajasthan, Jaipur-302004, Rajasthan, India
Narsingh Khatik ; Department of chemistry, University of Rajasthan, Jaipur-302004, Rajasthan, India
Abhinav Raj Khandelwal ; Department of chemistry, University of Rajasthan, Jaipur-302004, Rajasthan, India
Ravina Meena ; Department of chemistry, University of Rajasthan, Jaipur-302004, Rajasthan, India
Seema Bhadauria ; Department of Botany, University of Rajasthan, Jaipur-302004, Rajasthan, India
Malvika Singh ; Department of Botany, University of Rajasthan, Jaipur-302004, Rajasthan, India
Harshita Sachdeva orcid id orcid.org/0000-0002-1838-1863 ; Department of chemistry, University of Rajasthan, Jaipur-302004, Rajasthan, India *

* Corresponding author.

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Abstract

A new catalytic approach has been developed under microwave irradiation for the multicomponent reaction (MCR) of aromatic aldehydes, urea/thiourea and ethylacetoacetate to give corresponding dihydropyrimidinones (DHPMs) by using CuFe2O4/CuO-CeO2 nanoparticles (NPs) as heterogeneous and recyclable catalysts. 3, 4-Dihydropyrimidin-2(1H) ones/thiones are synthesized in higher yields (80-95 %) and short reaction time (8−10 minutes) at 245 Watts. It is applicable for both types of aromatic aldehydes containing EWS as well as EDS. Further, the synthesized compounds were evaluated for antibacterial activity against E. coli, B. subtilis, B. megaterium, and P. vulgaris. Among the compounds tested, ethyl-6-methyl-2-oxo-4-(4-chlorophenyl)-1,2,3,4-tetrahydropyrimidin-5-carboxylate, 4c showed response against B. subtilis, B. megaterium, and P. vulgaris and ethyl-6-methyl-2-oxo-4-(4-fluorophenyl)-1,2,3,4-tetrahydropyrimidin-5-carboxylate, 4h showed –ve response against E. coli, B. subtilis, B. megaterium, and P. vulgaris.

Keywords

CuFe2O4 NPs; CuO-CeO2 NC; green synthesis; Biginelli compounds; microwave irradiation

Hrčak ID:

308894

URI

https://hrcak.srce.hr/308894

Publication date:

17.10.2023.

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