Croatica Chemica Acta, Vol. 78 No. 3, 2005.
Original scientific paper
Oxidative Stress in Dairy Cows – Serum Paraoxonase Activity Related to Hepatomegaly
Romana Turk
Dubravka Juretić
Darko Gereš
Nenad Turk
Vera Simeon-Rudolf
Branka Rekić
Ante Svetina
Abstract
Association of serum paraoxonase (PON) activity and hepatomegaly in dairy cows as well as the relation between PON activity and HDL cholesterol concentration were studied considering the role of oxidative stress in reproductive and metabolic disorders in dairy caws. A significantly lower PON activity (P<0.01) was found in cows with hepatomegaly compared to clinically healthy cows. Concentrations of serum glucose, triglyceride and cholesterol were also markedly reduced in cows with hepatomegaly (P<0.001, P<0.001 and P<0.05, respectively), whereas the serum HDL cholesterol concentration showed no significant change. Paraoxonase/ HDL-cholesterol ratio in hepatomegaly was significantly lower (P<0.05) as well. As part of antioxidative defence against lipid peroxidation, lower PON activity contributes to an increased risk of oxidative stress in cows with hepatomegaly.
Keywords
paraoxonase; HDL-cholesterol; oxidative stress; dairy cows; fatty liver
Hrčak ID:
45
URI
Publication date:
15.9.2005.
Visits: 1.847 *