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Signa vitae : journal for intesive care and emergency medicine, Vol. 3 No. 2, 2008.

Review article

Human protein C concentrates in adult septic patients

GIOVANNI LANDONI orcid id orcid.org/0000-0002-8594-5980 ; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy
MARTINA CRIVELLARI ; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy
GIACOMO MONTI ; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy
CHIARA GERLI ; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy
PAOLO SILVANI ; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy
ALBERTO ZANGRILLO ; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy

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Abstract

Some case reports and case series suggest that protein C concentrates may improve the outcome in patients with congenital or acquired protein C deficiency (not only in those with sepsis induced purpura fulminans). We reviewed the published literature on the use of protein C concentrates in adult septic patients and found that it is limited to less than 70 patients reported in observational studies with a 70% survival, and added our personal experience (two adult patients with sepsis and contraindications to recombinant activated protein C).

Keywords

sepsis; protein C; cardiac surgery

Hrčak ID:

28697

URI

https://hrcak.srce.hr/28697

Publication date:

1.10.2008.

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