Pregledni rad
Human protein C concentrates in adult septic patients
GIOVANNI LANDONI
orcid.org/0000-0002-8594-5980
; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy
MARTINA CRIVELLARI
; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy
GIACOMO MONTI
; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy
CHIARA GERLI
; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy
PAOLO SILVANI
; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy
ALBERTO ZANGRILLO
; Department of Cardiothoracic Anesthesia and Intensive Care; Istituto Scientifico San Raffaele; Via Olgettina 60, Milano, 20132 Italy
Sažetak
Some case reports and case series suggest that protein C concentrates may improve the outcome in patients with congenital or acquired protein C deficiency (not only in those with sepsis induced purpura fulminans). We reviewed the published literature on the use of protein C concentrates in adult septic patients and found that it is limited to less than 70 patients reported in observational studies with a 70% survival, and added our personal experience (two adult patients with sepsis and contraindications to recombinant activated protein C).
Ključne riječi
sepsis; protein C; cardiac surgery
Hrčak ID:
28697
URI
Datum izdavanja:
1.10.2008.
Posjeta: 1.581 *