Original scientific paper
IMPACT OF METABOLIC THERAPY WITH TRIMETAZIDINE, PROPER NUTRITION AND PHYSICAL ACTIVITY ON QUALITY OF LIFE AND ON INCIDENCE OF REHOSPITALIZATIONS OF PATIENTS WITH ISCHEMIC HEART DISEASE
Una Suljić Fatić
; Faculty of Pharmacy, University Tuzla, Urfeta Vejzagića 8, 75000 Tuzla, Bosnia & Herzegovina
*
Besim Prnjavorac
; General Hospital, Tešanj, Braće Pobrića 17, 74260 Tešanj, Bosnia & Herzegovina
Sumeja Hadžalić
; Faculty of Pharmacy, University Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia & Herzegovina
Hana Helać
; Faculty of Pharmacy, University Sarajevo, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia & Herzegovina
* Corresponding author.
Abstract
Aim: To investigate whether additional treatment of ischemic heart disease with trimetazidine, proper nutrition and physical activity could decrease the number of rehospitalizations and overall quality of life of patients with ischemic heart disease. Methods: The study included 200 patients with ischemic heart disease. The sample is divided into 2 randomly selected groups: the experimental and control group. The diagnostic procedures included: trade-mill test according to Bruce protocol, heart ultrasound for assessment of ejection fraction, test for the assessment of quality of life and subjective problems (Short Form SF 36). Patients were tested on time of discharge from hospital, after 6 and 12 months, including reevaluation of the overall condition of the previous period. Results: Patients have been tested for the endurance of effort with the measurement Metabolic Equivalent of TASK (METs) which is the equivalent of physical labor. Patients treated with trimetazidine since the time of hospital discharge have achieved an average of 3.68, after 6 months 5.68, and after 12 months 7.79 METs. Control and experimental groups showed a significant difference in the number of hospitalizations for the periods of 6 months and 12 months after treatment. Fewer hospitalizations were in the group treated with trimetazidine than in those with only conventional therapy after 6 and 12 months. There is a significant difference in values Respondents' attitudes about how much they shortened their time at work or other activities as a result of physical health before starting therapy (Ppt <0.001), as well as for a period of 12 months after starting therapy shows a significant difference (P12 <0.001). The results we have for HDL and LDL after the clinical study show that patients who were on conventional therapy and trimetazidine and who used a proper diet as well as those who had physical activity, that their HDL and LDL values were better than at the beginning studies. Conclusion: Patients treated with conventional therapy including trimetazidine have better tolerance to effort and fewer hospitalizations in the comparison with those treated without trimetazidine, so trimetazidine has a beneficial effect on reducing the number of hospitalizations and productiveness at work and improving the quality of life. They had a better lipid status compared to patients who only used conventional therapy. BMI index was better in patients who used trimetazidine along with conventional therapy and had better psychological health.
Keywords
ischemic heart disease; quality of life with heart ischemia; metabolic therapy; rehospitalization
Hrčak ID:
314491
URI
Publication date:
21.2.2024.
Visits: 461 *