Review article

Liver Transplantation as Part of Multiorgan Transplantation – Opportunities and Challenges

Nikola Sobočan
Hrvoje Premec
Ivona Šarić
Božena Delija
Sandra Tipurić
Maja Mijić
Miloš Lalovac
Tajana Filipec Kanižaj

Abstract

Solid organ transplantation has become an essential part of the treatment of patients with end-stage diseases of the liver, kidney, heart, lungs, intestine and pancreas. Most transplantations are preformed separately, but multiorgan liver transplantation with either the kidney, heart or intestine has become an option. There are three major indications for combined and sequential liver kidney transplantations: terminal insufficiency of both organs, secondary end-stage renal failure in liver transplant recipients, and need for transplanting a new liver as a source of lacking enzyme or specific regulator of the immune system in a patient with renal failure. Combined liver heart transplantation is a treatment option to advanced heart failure with concomitant advanced hepatic disease. Intestine failure-associated liver disease (IFALD) is a lethal complication of long-term parenteral nutrition and short bowel syndrome. Visceral transplantation for IFALD includes variants of intestine, liver, or combined liver and intestine transplantation. Future efforts to standardize the criteria and indications for combined liver kidney, liver heart and liver intestine transplantation will optimize organ donation and utilization.

Keywords

solid organ transplantation; combined transplantation; multiorgan transplantation; simultaneous transplantation; sequential transplantation

Hrčak ID:

315865

URI

https://hrcak.srce.hr/315865

Publication date:

9.4.2024.

Article data in other languages: croatian

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