Review article

Exploration of new platforms and potentials in regenerative medicine

Nikola Štoković ; Laboratory for Mineralized Tissues, Centre for Translational and Clinical Research. University of Zagreb School of Medicine, Zagreb, Croatia
Natalia Ivanjko ; Laboratory for Mineralized Tissues, Centre for Translational and Clinical Research. University of Zagreb School of Medicine, Zagreb, Croatia
Marko Pećin ; Clinics for Surgery, Orthopedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Tatjana Bordukalo - Nikšić ; Laboratory for Mineralized Tissues, Centre for Translational and Clinical Research. University of Zagreb School of Medicine, Zagreb, Croatia
Vera Kufner ; Laboratory for Mineralized Tissues, Centre for Translational and Clinical Research. University of Zagreb School of Medicine, Zagreb, Croatia
Igor Erjavec ; Laboratory for Mineralized Tissues, Centre for Translational and Clinical Research. University of Zagreb School of Medicine, Zagreb, Croatia
Tamara Božić ; Genera Research, Kalinovica, Croatia
Marina Milešević ; Laboratory for Mineralized Tissues, Centre for Translational and Clinical Research. University of Zagreb School of Medicine, Zagreb, Croatia
Viktorija Rumenović ; Laboratory for Mineralized Tissues, Centre for Translational and Clinical Research. University of Zagreb School of Medicine, Zagreb, Croatia
Ivona Matić Jelić ; Laboratory for Mineralized Tissues, Centre for Translational and Clinical Research. University of Zagreb School of Medicine, Zagreb, Croatia
Valentina Blažević ; Laboratory for Mineralized Tissues, Centre for Translational and Clinical Research. University of Zagreb School of Medicine, Zagreb, Croatia
Ana Smajlović ; Clinics for Surgery, Orthopedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Hrvoje Capak ; Department of Radiology, Ultrasound Diagnostics and Physical Therapy, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Zoran Vrbanac ; Department of Radiology, Ultrasound Diagnostics and Physical Therapy, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Ana Javor ; Department of Radiology, Ultrasound Diagnostics and Physical Therapy, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Dražen Vnuk ; Clinics for Surgery, Orthopedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Hermann Oppermann ; Genera Research, Kalinovica, Croatia
Dora Adanić ; Genera Research, Kalinovica, Croatia
Mihaela Perić ; Center of Excellence for Reproductive and Regenerative Medicine, Zagreb, Croatia
Dražen Matičić ; Clinics for Surgery, Orthopedics and Ophthalmology, Faculty of Veterinary Medicine, University of Zagreb, Zagreb, Croatia
Slobodan Vukičević ; Laboratory for Mineralized Tissues, Centre for Translational and Clinical Research. University of Zagreb School of Medicine, Zagreb, Croatia

Abstract

Regenerative medicine is focused on the regeneration of various tissues and organs through the development of innovative therapeutic strategies and devices. Center of Excellence for Reproductive and Regenerative Medicine (CERRM) was established to provide necessary resources for conducting the state-of-the-art research in the field and to foster translation of developed therapeutic solutions to clinical practice. CERRM subunit for regenerative medicine has developed Osteogrow-C, a novel osteoinductive device for bone regeneration, which was successfully tested in various preclinical models including rabbit and sheep posterolateral spinal fusion (PLF) models as well as rabbit ulnar segmental defect model. Furthermore, CERRM has developed anti-BMP1.3 antibody-based therapy for various diseases that share fibrosis as a key pathological mechanism. This review paper provides the most important contemporary findings on the development of novel BMP-based devices for bone regeneration as well as the development of antifibrotic therapies.

Keywords

Osteogrow; Osteogrow-C; rhBMP6; bone regeneration; posterolateral spinal fusion; regenerative medicine

Hrčak ID:

318616

URI

https://hrcak.srce.hr/318616

Publication date:

25.6.2024.

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