Review article

Identical and Nonidentical Twin Drugs

M. Huzjak ; Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
Z. Rajić ; Faculty of Pharmacy and Biochemistry, Zagreb, Croatia
B. Zorc ; Faculty of Pharmacy and Biochemistry, Zagreb, Croatia

Abstract

Twin drugs contain two pharmacophoric groups combined covalently in a single molecule. Pharmacophoric groups can be identical moieties (identical twin drugs) or different (nonidentical twin drugs). Identical twin drugs can act on receptors (biogenic amine receptors, peptide receptors, Ca2+ channel, σ receptors in the brain, leukotriene B₄ receptors), as enzyme inhibitors (HIVenzyme, protein kinase, prolyl hydrolase, acyl-CoA cholesterol acyl transferase, spermidine- spermine-N1-acetyltransferase, S-adenosylmethionine decarboxylase), and as DNA ligands. Nonidentical twin drugs exert their dual action on two different receptors, on two binding sites of a single receptor, on two enzymes, or on both a receptor and an enzyme.

Keywords

twin drugs; receptors; enzymes

Hrčak ID:

29417

URI

https://hrcak.srce.hr/29417

Publication date:

5.11.2008.

Article data in other languages: croatian

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