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Journal of Electrochemical Science and Engineering, Vol. 14 No. 5, 2024.

Original scientific paper

https://doi.org/10.5599/jese.2462

Electrochemical sensor for acetylcholine detection based on WO3 nanorods-modified glassy carbon electrode

Peyman Mohammadzadeh Jahani ; School of Medicine, Bam University of Medical Sciences, Bam, Iran
Reza Zaimbashi ; Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
Mohammad Reza Aflatoonian ; Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran
Somayeh Tajik ; Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, Iran
Hadi Beitollahi ; Environment Department, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran

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Abstract

Acetylcholine (ACH) is one of the excitatory neurotransmitter in the human body. It is the most abundant neurotransmitter responsible for triggering the activation of postsynaptic neurons, leading to an excitatory response. ACH plays a crucial role in various physiological processes, including muscle contraction, autonomic nervous system regulation, and cognitive functions such as learning and memory. In this study, an electrochemical sensor was prepared based on WO3 nanorods modified glassy carbon electrode for the detection of ACH. The WO3 nanorods provided excellent properties for the electrochemical determination of ACH. The proposed sensor exhibited a wide linear detection range of (0.1 to 400.0 µM) and a low detection limit of 0.025 µM for ACH. These results demonstrate the sensor's high sensitivity in detecting this important neurotransmitter. In addition the developed sensor showed good ability for ACH determination in real samples. This study offers an innovative strategy for the electrochemical detection of ACH, showcasing the potential of nanomaterials in the development of advanced sensing technologies.

Keywords

Cyclic voltammetry; differential pulse voltammetry; modified electrodes; real sample analysis; neurotransmitter

Hrčak ID:

321289

URI

https://hrcak.srce.hr/321289

Publication date:

1.10.2024.

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